When other relatives and friends sought his tutoring, he moved his tutorials to YouTube, where he created an account on November 16, 2006. In 2004, Khan began tutoring his cousin, Nadia, in mathematics over the internet using Yahoo!'s Doodle notepad. From 2003 to late 2009, he worked as a hedge fund analyst at Connective Capital Management.

In 2002, Khan was a summertime intern at PARC. Khan also holds a Master of Business Administration from Harvard Business School. In his final year, Khan was the president of the 'Senior Gift Committee,' a philanthropy program of the graduating class. He attended the Massachusetts Institute of Technology (MIT), graduating with Bachelor of Science and Master of Science degrees in Course 6 ( electrical engineering and computer science), and another bachelor's degree in Course 18 ( mathematics), in 1998. Khan took upper-level mathematics courses at the University of New Orleans while he was in high school and graduated as valedictorian in 1994. He attended Grace King High School, where, as he recalls, 'a few classmates were fresh out of jail and others were bound for top universities.' He was a cartoonist for the high school's newspaper. His mother, Masuda Khan, is from Murshidabad in West Bengal, India.

Khan's grandfather, Abdul Wahab Khan was the 3rd Speaker of the National Assembly of Pakistan. They are descended from Rahmat Khan, a Pathan chieftain who was killed in conflict with Raja Kandarpanarayan Rai of Chandradwip in the 16th century. His father was a physician, and originally hailed from the village of Rahmatpur in Babuganj, Barisal District, Bangladesh.

1990) and Masuda Khan in Metairie, Louisiana. Salman Amin Khan was born on Octoto Bengali Muslim parents Fakhrul Amin Khan (d.

Salman khan math